The Imaginative Institution: Planning and Governance in Madrid

Every 20 years since 1920 Madrid has undergone an urban planning cycle in which a city plan was prepared, adopted by law, and implemented by a new institution. This sequence, along with the institution's structures and procedures, has persisted - with some exceptions - despite frequent upheavals in society. The planning institution itself played a key role in maintaining continuity, traumatic history notwithstanding. This book presents an empirically based life cycle theory of institutional evolution that suggests that the constitutional image sustaining the institution undergoes a change or is replaced by a new image, leading to a new or reformed institution

Planning and Leadership

A handbook for use by planning academics and educators and students around the world, covering all topics of urban planning

Infrastructure is Key to Make Cities Sustainable

Infrastructure is all around us: under, above, even inside our built and natural landscapes. Sometimes hidden, sometimes visible. The flows that course through them make our cities, economies, and lives possible. Cities could not even exist without infrastructure. Life is endowed with more possibilities by infrastructure. The centrality of infrastructure is pervasive. Worldwide, cities embrace infrastructure for economic competitiveness, well-being, access, environmental protection and knowledge creation. As cities are crucibles that concentrate the human condition, infrastructures are conduits that enable that concentration and empower human achievement. As infrastructures shape almost every aspect of daily life, this article assays the various ways it currently makes places both less sustainable and resilient, as well as more so, and how we can minimise the former and optimise the latter

Measuring Sustainability

Planning for sustainability is high on many agendas, and tools to measure sustainability have been developed. Sustainable processes are those whose rates are maintained over time without exceeding the innate ability of its surroundings to support the process. We present the necessary conditions along with a new algorithm for measuring the sustainability of processes that integrates the laws of thermodynamics with laws for rate processes. The algorithm permits the assessment of the degree of sustainability of any process, whether ecological, economic, or social, as well as chemical or biological. It is a dynamic approach that applies at any scale and takes into consideration the spatial and temporal factors of processes, thus permitting empirical applications that correspond to real world (dynamic, complex, evolving) conditions across space and time. These characteristics make it especially suitable for applications in the field of spatial planning

Building California's Future

Current conditions in infrastructure planning, budgeting and financing in the state of Californi

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs

Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who manifested HSRs clinically, to correlate LTA results with the clinical syndrome, to correlate LTA results with the human leukocyte antigen (HLA) allele B*1502 (HLA-B*1502) positivity in a Han Chinese-Canadian population, and to determine the cytokine network in this population. HSR patients developed fever and cutaneous eruptions in the presence or absence of organ involvement within 8 weeks of exposure to carbamazepine (CBZ), phenytoin (PHY) or lamotrigine (LTG). Control patients received AEDs without presenting HSR. We investigated 10 CBZ-HSR (4 presented with Stevens-Johnson syndrome (SJS)), 24 CBZ-controls, 10 PHY-HSR (4 presented with drug-induced liver injury (DILI)), 24 PHY-controls, 6 LTG-HSR (1 SJS and 1 DILI) and 24 LTG-controls. There were 30 Han Chinese individuals (14 HSR patients and 16 controls) in our cohort. LTA toxicity greater than 12.5%±2.5% was considered positive. Differences among groups were determined by analysis of variance. In addition, we measured cytokine secretion in the patient sera between 1 month and 3 years after the event. All Han Chinese individuals and 30% of Caucasians were genotyped for HLA-B*1502.A perfect correlation (r=0.92) was observed between positive LTA and clinical diagnosis of DILI and SJS/toxic epidermal necrolysis (TEN). HLA-B*1502 positivity in Han Chinese is a predictor of CBZ-HSR and PHY-HSR. HLA-B*1502-negative Han Chinese receiving only CBZ or a combination of CBZ-PHY tolerated the drug(s) clinically, presenting negative CBZ-LTA and PHY-LTA. However, 3 patients presenting negative CBZ-LTA and PHY-LTA, as well as negative HLA-B*1502, showed positive LTG-LTA (38%, 28% and 25%, respectively), implying that they should not be prescribed LTG. Three patients had LTA positive to both PHY and CBZ, and 3 others had LTA positive to both PHY and LTG. Clinically, all six patients presented HSR to both drugs that they tested positive to (cross-reactivity). Patients were grouped based on the clinical presentation of their symptoms as only rash and fever or a triad that characterizes "true" HSR (rash, fever and DILI or SJS/TEN). Levels of pro-inflammatory cytokines were significantly higher in patient sera compared to control sera. More specifically, the highest levels of tumor necrosis factor (TNF)-α was measured in patients presenting "true" HSR, as were the apoptotic markers Fas, caspase 8 activity and M30. We concluded that LTA is sensitive for DILI and SJS/TEN regardless of drug or ethnicity. HSR prediction will prevent AED-induced morbidity. In Han Chinese, HLA-B*1502 positivity is a predictor for CBZ-HSR and PHY-HSR. Its negativity does not predict a negative LTG-HSR. There is cross-reactivity between AEDs. Additionally, T-cell cytokines and chemokines control the pathogenesis of SJS/TEN and DILI, contributing to apoptotic processes in the liver and in the skin